TP53 and cancer: The results revealed that in the C3 subtype, the activity levels of cell proliferation-related pathways (such as MYC targets, DNA repair, E2F targets, and the G2M checkpoint), oncogenic pathways (such as TGF beta, Notch, WNT beta catenin, and P53), and metabolic pathways (such as glycolysis and mTORC1 signaling) were the highest, indicating that the cancer cells in this subtype were highly proliferative (Figure 3E).