IL1R1 and intervertebral disk degenerative disorder: To elucidate the characteristics of diabetes-associated IDD, gene set enrichment analysis (GSEA) of IL1R1 was performed, highlighting its association with seven key pathways: DNA mismatch repair, N-glycan biosynthesis, primary immunodeficiency, base excision repair, DNA replication, homologous recombination, and asthma.