As a ubiquitin E3 ligase, UBE3C plays a role in the degradation of the PEBP1 protein within ccRCC cells via the ubiquitin-proteasome system (86).CircPOLR2A can directly bind to PEBP1 and UBE3C. The gene discussed is UBE3C; the disease is nonpapillary renal cell carcinoma.