40S ribosomal protein S3(RPS3) has the ability to augment the NF-κB signaling pathway and is involved in the physiological processes related to chemotherapy resistance, the proliferation of tumor cells, and the metastasis of diverse tumors (45–47); Heat shock protein 90 (HSP90) is capable of interacting with RPS3. This evidence concerns the gene RPS3 and neoplasm.