In bladder cancer, one of the most common urinary system malignancies, ubiquitin carboxy-terminal hydrolase L1 (UCHL1) directly binds to PKM2 and inhibits its ubiquitin-mediated degradation, leading to increased PKM2 protein levels and subsequently enhancing aerobic glycolysis, metastasis, and invasive activity (81). The gene discussed is PKM; the disease is urinary bladder cancer.