PKM and neoplasm: The anti-tumor efficacy achieved by disrupting the homologous recombination pathway operates primarily through two mechanisms: firstly, SHK itself induces increased intracellular reactive oxygen species, leading to DNA double-strand breaks; secondly, SHK directly inhibits PKM2, thereby amplifying the effects of olaparib in inducing γH2AX upregulation, ATM phosphorylation activation, and BRCA1 downregulation (140).