PKM and pachyonychia congenita: Additionally, in the context of castration-resistant PC, the tanshinone IIA analog TB3 has been identified as an effective therapeutic agent, inhibiting the degradation of androgen receptor (AR), concurrently reducing AR nuclear translocation and thereby affecting AR-mediated transcription pathways of key ARE-containing genes, ultimately downregulating PKM2 expression by targeting this AR/PKM2 axis to suppress aerobic glycolysis (136).