PKM and neoplasm: Histone deacetylase 8 (HDAC8) interacts with the PKM2 protein to perform deacetylation modification at position K62, reducing its cytoplasmic catalytic activity in glycolysis; however, this modification simultaneously facilitates PKM2 nuclear translocation, where it interacts with β-catenin to drive CCND1 transcription, disrupting cell cycle control and exacerbating tumor progression (49).