ITGAM and cyclic hematopoiesis: These genes negatively regulated IL-2, and subsequently, through the STAT5 and MTORC1 pathways, they positively regulated (CD27 on IgD- CD38+ B cells) and (CD27 on switched memory B cells)/CD244 and negatively regulated (CD33dim HLA DR+ CD11b- Absolute Count)/IL-18 and (CD28+ CD4-CD8- T-cell %T cell)/OPG, promoting the progression of CH.