Batch MR screening revealed that IL-2 promotes the progression of CH by positively regulating (CD27 on IgD-CD38+ B cells) and (CD27 on switched memory B cells)/CD244 and negatively regulating (CD33dim HLA DR+ CD11b-absolute count)/IL-18 and (CD28+ CD4-CD8-T-cell %T cell)/OPG. Here, CD28 is linked to cyclic hematopoiesis.