DISC1 and schizophrenia: Research using animal models emphasizes the important role of DISC1 in the communication between GABAergic interneurons and pyramidal neurons (Sauer and Bartos, 2022), while both in vitro and in vivo studies have demonstrated that mutations in DISC1 lead to cytoarchitectural abnormalities in the cerebral cortex (Kamiya et al., 2005; Norkett et al., 2016) or behavioral changes resembling those seen in schizophrenia (Hikida et al., 2007; Niwa et al., 2013).