CD-30+ cutaneous lymphoproliferative disorders account for 30% of all CTCL, and includes lymphomatoid papulosis, primary cutaneous anaplastic large cell lymphoma (PC-ALCL), and borderline lesions, and constitute the second most common group of CTCL after mycosis fungoides and Sezary syndrome [1]. The gene discussed is TNFRSF8; the disease is Sezary syndrome.