In line with motor coordination deficits observed in these mice, and consistent with findings from other epilepsy and neurodegenerative disease models,84, 85 our electrophysiological data reveal altered cortico‐striatal transmission in the dorso‐lateral striatum of both Epm2a−/− and Epm2b−/− mice, characterised by a significant increase in sEPSC frequency. This evidence concerns the gene EPM2A and epilepsy.