KLF4 and obesity due to melanocortin 4 receptor deficiency: Additionally, genes involved in white fat differentiation and adipogenesis pathways were downregulated by OJ consumption, including KLF4 (−2.3), RIPK1 (−1.7), PLIN2 (−1.99), and CXCL8 (−34.43); genes found as overexpressed in obesity [43, 44, 45, 46].