The main pathways involved include the focal adhesion‐PI3K‐Akt‐mTOR‐signaling pathway; AhR; fluid shear stress and atherosclerosis; protein processing in endoplasmic reticulum; thermogenesis; adipogenesis; and several inflammatory‐related pathways (IL‐5, IL‐2, TGF‐β receptor, and IL‐6 signaling) (Figure 3C). The gene discussed is IL5; the disease is atherosclerosis.