The co‐staining of GFAP and TS/Aβ with microtubule‐associated protein 1A/1B‐light chain 3 (LC3) or phosphorylated autophagy‐related Gene 16‐Like 1 (p‐Atg16L1), two key autophagic markers, showed that microglial Rack1 knockout upregulated the staining intensity of LC3 and p‐Atg16L1 in astrocytes surrounding Aβ plaques in the AD mouse (Figure S8E–H, Supporting Information). This evidence concerns the gene MAP1LC3A and Alzheimer disease.