Alzheimer's disease (AD) is characterized by extracellular amyloid beta (Aβ) deposition, intraneuronal tau hyperphosphorylation, and neuroinflammation, leading to synaptic loss, neuronal cell death, and, ultimately, cognitive impairment.[1, 2] Despite AD being one of the most prevalent diseases among older people, the molecular mechanisms contributing to its pathophysiology are still not fully understood. Here, MAPT is linked to Alzheimer disease.