Notably, the CD47 antibody B6H12, known for its interference with the CD47/SIRPα axis, further enhanced phagocytosis when combined with the αvβ3 antibody 23C6 (B6H12 vs B6H12 + 23C6, p < 0.001, Student's t‐test; Figure S9I, Supporting Information), indicating the involvement of αvβ3 in the regulation of the tumor–macrophage CD47/SIRPα axis. This evidence concerns the gene CD47 and neoplasm.