Transient knockdown of αv in other malignant cells, such as colon cancer cells HCT116, non‐small‐cell lung cancer A549, and glioma cells U87, also resulted in a significant decrease in the expression of αvβ3 and CD47 on the membrane of the cancer cells (p < 0.01 or p < 0.001 compared to control, Student's t‐test; Figure S5D–F, Supporting Information). This evidence concerns the gene CD47 and central nervous system cancer.