Second, while factors influencing αvβ3 activation, such as alterations in calcium concentration,[49] the presence of the activating ligand FN and the key intracellular proteins Talin and Kindlin,[62] affect the stable coexpression of αvβ3 and CD47 on the membrane of cancer cells, their effect is only one‐third of that of the effect of αv‐siRNA knockdown (Figure 5; Figure S12, Supporting Information). Here, FN1 is linked to cancer.