To delve deeper, we conducted an extensive computational analysis using the Z‐dock algorithm,[50] incorporating structural data of the extracellular structural domain of CD47 (CD47‐ECD)/SIRPα complex (PDB ID: 2JJT)[51] and the closed conformer of αvβ3 (PDB ID: 3IJE).[52] Exclusion of certain αvβ3 domains distant from the membrane, such as β‐propeller, Thigh, β I‐like, PSI, etc. (Figure S14A,B, Supporting Information), yielded a plausible interaction model between macrophage SIRPα and CD47/αvβ3‐ECD on tumor cells (Figure 6B; Figure S14C, Supporting Information). Here, SIRPA is linked to neoplasm.