CD47 and neoplasm: Although both αvβ3 and CD47 are abundantly expressed in a variety of malignancies, it is suggested that targeting either CD47 or αvβ3 alone is not very sufficient for cancer treatment.[30, 31] Human erythrocytes express CD47 but not αvβ3, while in vitro protein immunoprecipitation also revealed direct interaction between αvβ3 and CD47.[32, 33, 34] These findings raise several questions:[35, 36] are αvβ3 and CD47 on tumor cells functionally connected through direct interactions?