Furthermore, disruption of the CD47/αvβ3–SIRPα signaling in human‐tumor‐bearing NSG mice led to attenuated tumor growth and significantly prolonged survival, thereby providing further evidence of the pivotal role that membrane colocalization and structural integrity of CD47/αvβ3–SIRPα complexes play in tumor immune escape (see below). This evidence concerns the gene SIRPA and neoplasm.