CD47, highly expressed on tumor cells, binds to SIRPα on macrophages, forming CD47–SIRPα immune checkpoints that facilitate tumor evasion from macrophage phagocytosis.[2] Given this, we hypothesized that the concomitant presence of CD47 and αvβ3 on cancer cell membranes might have functional implications for the CD47–SIRPα axis. The gene discussed is SIRPA; the disease is cancer.