In vivo, ventral hippocampal (vHip) overexpression of miR‐485‐5p or targeted knockdown of THUMPD3‐AS1 rescued MK‐801‐induced SCZ‐like phenotypes (anxiety, cognitive deficits, and social memory impairments) and restored synaptic ultrastructure. The gene discussed is THUMPD3; the disease is Anxiety.