In general, TGFβ2/TGFβR2/Smad3 is a typical TGFβ signaling in oral cancer cells and myogenic or chondrogenic progenitor cells.[46, 47] However, the roles of this signaling in trophoblast cell migrasome formation and miscarriage are still completely unknown. The gene discussed is SMAD3; the disease is lip and oral cavity carcinoma.