BLM stimulation induced lung injury/fibrosis-associated changes in the organoids, and scRNA-seq analysis of the organoids revealed the emergence of two ABC-like subsets (ABCs_1 and ABCs_2), which were defined by the expression of Krt17, Fn1, and variable levels of Krt5 and Trp63; however, they lacked canonical AECs markers such as Sftpc and Hopx, as observed in human IPF lungs. This evidence concerns the gene KRT5 and idiopathic pulmonary fibrosis.