We identified two IPF-related ABC clusters (Muc5b− Scgb1a1− Krt17+Fn1+Krt5low ABCs_1 and Muc5b− Scgb1a1−Krt17+Fn1+Krt5+ABCs_2) in our murine organoid model (Fig. 3 D and E). Here, MUC5B is linked to idiopathic pulmonary fibrosis.