The upregulated DEGs associated with the enriched GO terms in AT2 cells of BLM-stimulated lung organoids, such as Cdkn1a, Trp53inp1, Rps27l, Cd81, and Gclc, increased in expression from day 3 post-BLM administration in AT2 cells in vivo (as shown in Supplementary Fig. S4B in Supplementary Figures). The gene discussed is GCLC; the disease is Bloom syndrome.