Even in this analysis, Enrichr reported confusing, poorly-defined gene sets scraped from PubMed supplemental tables (“PMC5189935-pmed.1002201.s013.xlsx-HR HER2- Amplification-1Q21 3 1 ERBB2”) and bio-knowledgebases (“Keratoderma hereditarium mutilans with ichthyosis ORPHA:79,395” from Orphanet_Augmented_2021 and “Tumor Endothelial cell:Kidney” from CellMarker_Augmented_2021), confounding the true biological signal. The gene discussed is ERBB2; the disease is ichthyosis.