CASP8AP2 and malignant colon neoplasm: However, only GeneTEA identified that CASP8AP2 and HINFP also have replication-related histone function—CASP8AP2 was shown to regulate the expression of replication-dependent histone mRNA during S phase in colon cancer [46], while HINFP is a transcriptional activator that promotes the expression of histone H4 genes at the G1/S phase transition [47].