Beyond this professionally binding textbook, there are some new reports addressing other CNS tumor types not covered so far concerning NF1, such as embryonal tumors [36, 37], e.g., embryonal tumor with multilayered rosettes, diffuse low-grade astrocytoma (WHO grade 2–3), SEGA-like astrocytomas, diffuse midline glioma H3K27M mutant, and low-grade astrocytoma with interdeterminate subtype [1, 37]. The gene discussed is NF1; the disease is central nervous system neoplasm.