SHH and medulloblastoma: Specifically, WNT activated and group 3 medulloblastoma are frequently associated with heterozygous variants in SMARCA4 [15].In addition, functional SMARCA4 or even an epigenetic regulation for increased BRG1 expression plays an essential role in tumorigenesis in other tumor entities such as group 4 and sonic hedgehog (SHH) activated medulloblastoma or glioblastoma [11]