CYBB and neoplasm: In terms of molecular mechanisms, clusters #1 “Gene Expression”, #3 “Apoptosis”, #6 “β-catenin”, and #7 “NOX2” reflect sustained interest in pollutant-induced tumor promotion, encompassing transcriptional regulation, cell death pathways, oncogenic signaling such as Wnt/β-catenin, and oxidative stress mediated by NADPH oxidase 2.