Among the genes showing the top dependency scores, four genes were associated with APL-specific super enhancers bound with PML-RARA and they were also upregulated in APL: CNOT7, ACTG1, P2RY2, and TBC1D2B. CNOT7 has reported to be involved in cell proliferation [55] and ACTG1 is a cell adhesion gene, reported to be downregulated in KMT2A::MLLT10 AML patients [56] and potentially affecting leukemia progression. The gene discussed is TBC1D2B; the disease is acute promyelocytic leukemia.