Several of the top 20 APL super enhancers are linked to genes known to have functional roles in leukemia, for example RNF216, FSCN1, FNDC3B, HSP90B1, C12orf75, and JARID2 (Fig. 3a), among them, JARID2 is a hematopoietic tumor suppressor through recruiting PRC2 to repress self-renewal pathways [54]. Here, RNF216 is linked to acute promyelocytic leukemia.