SHBG and breast cancer: Notably, a missense mutation in the NIPBL gene was predicted to be “possibly damaging.” Among the seventeen genes with human orthologs associated with breast cancer, mutations in the CDH1, SHBG, PALB2, ERBB2, CDKN2A, STK11, and BRCA2 genes were identified in all the MGT tissues but not in the blood sample.