TREM2 and Alzheimer disease: This approach involves transplantation of microglia derived from TREM2 wild-type-AD mice into TREM2 KO-AD mice or TREM2 R47H-AD mice via bone marrow transplantation to restore microglial function and ameliorate AD pathology [325, 326], or transplantation of hematopoietic stem cells transduced with a lentivirus overexpressing TREM2 into AD mice, leading to decreased Aβ deposition and reduced neuroinflammation [327].