In addition to this unique transcriptional activation state, human AD microglia also exhibit an enhanced human aging profile compared to microglia from older subjects [377], including upregulation of senescence-associated genes (such as IL15, MS4A6A, MS4A4A, NME8, and GPR141) and downregulation of genes with lower expression in microglia from older subjects (such as CECR2) [377]. Here, GPR141 is linked to Alzheimer disease.