The top 10 core targets of YQWYF for DKD treatment included mainly TNF, IL6, AKT1, GAPDH, BCL2, ESR1, SRC, CTNNB1, EGFR, and PPARG (Fig. 1D), and the targets ranking and topological parameters of top 10 targets was showed in Fig. 1E and Table 1. This evidence concerns the gene GAPDH and diabetic kidney disease.