The study revealed that immune senescence markers (CD57+KLRG1+) (3.5 ± 5.49, 3.1 ± 1.27) were significantly overexpressed in newborns from the diseased parent (diabetes, hypertension) (p = 0.04), and particularly KLRG1+ expression was positively correlated with both maternal and paternal TLs (mother: r = 0.395; p = 0.003, father: r = 0.32; p = 0.014). The gene discussed is KLRG1; the disease is diabetes mellitus.