HAND1 and gastrointestinal stromal tumor: To contextualize MITF within the transcriptional regulatory landscape of GIST, we compared MITF ChIP-seq peaks with publicly available datasets for known GIST transcription factors and chromatin regulators, including ETV1, a lineage-specific transcription factor in GISTs [25], HAND1, a transcriptional determinant implicated in the malignant progression of aggressive GISTs [26, 27], and the active enhancer histone mark H3K27ac [28].