Furthermore, given the reported associations of ZNF334, Hsp90 and TRPM8 with tumor progressions (Cheng et al, 2022; Condelli et al, 2019; Jafari et al, 2020; Liu et al, 2016; Yang et al, 2023), and the potential of cancer hyperthermia therapies (Dewhirst et al, 2016; Kalamida et al, 2015), this study also provides hints in thermal modulation of tumor stress responses. Here, TRPM8 is linked to neoplasm.