For example, the patient’s cold-induced urticaria-like rash, fever, arthralgia, and progressive SNHL, accompanied by enhanced monocyte NLRP3 signaling and IL-1β production, corresponded with the features of disorders caused by autosomal dominant NRLP3 gain-of-function mutations (Moltrasio et al, 2022). This evidence concerns the gene NLRP3 and sensorineural hearing loss disorder.