Cryopyrin-associated periodic syndromes (CAPS) encompass a spectrum of autoinflammatory disorders that result from dominant mutations in NLRP3, leading to hyperactivation of the NLRP3 inflammasome in monocytes and macrophages (Moltrasio et al, 2022; Romano et al, 2022). This evidence concerns the gene NLRP3 and cryopyrin-associated periodic syndrome.