Healthy and AMD iPSC-RPE showed similar flux of ATG8-family proteins (GABARAPL1), mitophagy receptors (BNIP3) and selective autophagy adaptors (CALCOCO2/NDP52, SQSTM1/p62, TAX1BP1) upon lysosomal degradation inhibition with N/L (Fig. EV6L), indicating that macroautophagy is indeed fully functional in both backgrounds. The gene discussed is TAX1BP1; the disease is age-related macular degeneration.