AMD iPSC-RPE presented a very robust increase in 4-HNE levels (Fig. 2K), and treatment with CA77.1 induced a significant increase in the mRNA levels of the transcription factor NFE2L2/NRF2 (Figs. 5A and EV7B), a master regulator of the antioxidant response and positive modulator of CMA (Pajares et al, 2018a). This evidence concerns the gene NFE2L2 and age-related macular degeneration.