ACSL4 and age-related macular degeneration: AMD donor-derived iPSC-RPE cells indeed present functional macroautophagy but decreased levels of the CMA transcriptional network, including the receptor LAMP-2A, concomitant with impaired antioxidant response, increased lipid peroxidation, and accumulation of ferroptosis mediators known to undergo degradation via CMA, such as ACSL4.