In both hormone-dependent breast and prostate cancers, FOXA1 forms a triumvirate with a GATA protein and an NR (GATA3 and ER in breast cancer; GATA2 and AR in prostate cancer) and is the foundational protein in these cancers35,36 due to its ability to create new enhancer elements37. This evidence concerns the gene QRSL1 and Familial prostate cancer.