Analysis of the H3K27Ac sites showed that the most enriched motifs within all experimentally mapped enhancer elements from patient samples were hepatocyte nuclear factor (HNF) motifs (HNF4G and HNF4A) and Forkhead (that is, FOXA1; Fig. 1a), confirming that these two classes of transcription factors constitute the lineage-defining factors in these patient tumor samples. Here, HNF4A is linked to neoplasm.