In both hormone-dependent breast and prostate cancers, FOXA1 forms a triumvirate with a GATA protein and an NR (GATA3 and ER in breast cancer; GATA2 and AR in prostate cancer) and is the foundational protein in these cancers35,36 due to its ability to create new enhancer elements37. The gene discussed is ESR1; the disease is prostate carcinoma.