DCT and neoplasm: Then, aiming to assess whether any of the tumour clusters have shifted from a differentiated melanocytic state to a more undifferentiated or mesenchymal-like/invasive state34, we compared the expression levels of melanocytic (TYR, MLANA, DCT and MITF) and mesenchymal (ZEB1, VIM, FN1 and AXL) marker genes in the tumour clusters.