Additionally, the miRDB database57, based on predictive algorithms, indicates the presence of 215 miRNAs targeting the 3’UTR of the CCNG2 gene in the human, 48 miRNAs for PGS1’s 3’UTR, 174 miRNAs for RTF1 and 199 miRNAs for SPCS3. These examples demonstrate a mechanism whereby shortening the 3’UTR by shifting it towards proximal polyadenylation sites can eliminate miRNA regulatory elements, leading to increased expression of genes critical for the immune and metabolic response in COVID-19. Here, SPCS3 is linked to COVID-19.