In this context, shortening its 3’UTR may affect mitochondrial homeostasis, which is particularly relevant in the pathophysiology of COVID-19 The RTF1 protein is a component of the Paf1/RNA polymerase II transcription complex and is a confirmed target of at least 21 human miRNAs evidenced within the mirTarBase database56 (including CLIP-Seq method). Here, PAF1 is linked to COVID-19.