Within the dataset analyzed in this study, 4 out of 27 genes (14,8%) showed the 3′UTR shortening mechanism via APA (Δusage < −0.3), providing specific examples of potential escape from miRNA regulation in COVID-19 patients: CCNG2, PGS1, RTF1 and SPCS3 (Fig. 5A, B; Supplemental Table 10). Here, SPCS3 is linked to COVID-19.