Genes exhibiting significantly different APA site usage towards COVID-19 patients included BMI1 proto-oncogene, polycomb ring finger (BMI1), JAZF zinc finger 1 (JAZF1), NIPBL cohesin loading factor (NIPBL), and DEAD-box helicase 46 (DDX46), while in control patients, RTF1 homolog, Paf1/RNA polymerase II complex component (RTF1), phosphatidylglycerophosphate synthase 1 (PGS1), signal peptidase complex subunit 3 (SPCS3), and cyclin G2 (CCNG2) were identified (Fig. 5A). This evidence concerns the gene PGS1 and COVID-19.