Moreover, research using APP transgenic mice (APPswe/PS1dE9) indicated that Aqp9 downregulation could exacerbate Aβ-induced neurotoxicity, facilitate Aβ-mediated Alzheimer’s disease progression, disrupt synaptic function, and promote apoptosis46,thus, indicating the key role of Aqp9 in preserving neuronal vitality. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.