The changes in the expression of stemness-associated markers (downregulation of E-cadherin and upregulation of N-cadherin, vimentin, snail, SOX2, CD44, OCT4, and Nanog) indicated that high intracellular ATP levels could promote GC cell stemness by activating the PI3K/AKT signaling pathway. The gene discussed is SOX2; the disease is gastric cancer.