ENO1 and neoplasm: These characteristics support its potential for both targeted treatments (such as antibody- or vaccine-based strategies)13,25,29,30 and noninvasive biomarker development.31,32 In addition to its established roles in interacting with YAP1, promoting MMP expression, and functioning as an RNA-binding protein,15,17 ENO1 has been increasingly recognized for its involvement in tumor progression.