ENO1 and gastric cancer: AICAR increased the level of phosphorylated AMPK in ENO1-overexpressing cells, indicating reversion of AMPK/mTOR pathway inactivation induced by ENO1 (Fig. 2h; Supplementary Fig. 2d); AICAR also weakened the sphere formation, migration, and invasion abilities (Fig. 2i; Supplementary Fig. 2e) of ENO1-overexpressing GC cells.