Importantly, for the remaining nine PGVs that were identified in genes with a strong association with familial glioblastoma or medulloblastoma (SUFU, MSH6 (2x), PMS2 (5x) and BRCA1), a second (somatic) event and/or a matching mutational signature was identified in the tumor. The gene discussed is SUFU; the disease is glioblastoma.