ACP5 and periodontitis: Notably, both Gala-SR and SR1078 treatment groups exhibited a marked reduction in TRAP-positive cell numbers relative to the DMSO-treated periodontitis controls, indicating suppressed osteoclastic activity (Fig. 7b) and further substantiated the superior efficacy of Gala-SR in suppressing osteoclast activities and inflammation within the periodontal tissue in Jet Lag mice.