Considering that previous studies have identified clock-amplitude-enhancing molecules (CEMs) to ameliorate circadian rhythm disorders.48 Apparently, the patterns of Gala-SR affecting the circadian genes and inflammatory activities in periodontal tissue affirmed itself a CEM that targeted activates RORα to restore the circadian rhythm of periodontal tissue, thereby alleviating periodontitis and alveolar bone loss, thus demonstrating great promise in the therapeutic interventions of circadian rhythm disorder and related inflammatory diseases. This evidence concerns the gene CLOCK and periodontitis.