2008; Maji et al. 2017), activating pro‐survival signaling pathways such as the PI3/Akt axis to enhance DNA repair and cell proliferation (Putz et al. 2012), and suppressing apoptosis through microRNA‐mediated regulation (Bronisz et al. 2014). In pediatric high‐grade gliomas, prior studies have shown that H3K27M‐pDMG‐derived sEVs influence gene expression in neural stem cells (Tűzesi et al. 2017) and exhibit subclone‐specific miRNA content (Pericoli et al. 2023). This evidence concerns the gene PI3 and central nervous system cancer.