Unlike its role in other cancers, where YTHDF1 primarily stabilizes c-MYC mRNA, in NPC it exerts dual posttranscriptional control: prolonging c-MYC mRNA half-life to enhance stability and increasing translational efficiency (confirmed by ribosome profiling) to elevate c-MYC protein levels, forming a coordinated regulatory network. This evidence concerns the gene MYC and cancer.