However, distinct from their findings, our data further demonstrated that YTHDF1 exerts a more comprehensive regulatory effect on c-MYC in NPC: the mRNA expression of MYC was higher in the WT cell lines than in the YTHDF1-KO cell lines, and c-MYC expression decreased in the stable YTHDF1-KO cell lines (Fig. 3D), suggesting that YTHDF1-mediated regulation is not limited to stability but involves multilevel modulation. This evidence concerns the gene YTHDF1 and nasopharyngeal carcinoma.