To our knowledge, these m6A motifs (AAACT and GAACA within the CRD) are unreported in NPC and distinct from the 3′ untranslated region -localized GGACU motif targeted by METTL3/YTHDF1 in oral squamous cell carcinoma (22), highlighting a tissue-specific m6A code for c-MYC regulation. This evidence concerns the gene METTL3 and oral cavity squamous cell carcinoma.