ANKRD26-related thrombocytopenia (ANKRD26-RT), ETV6-related thrombocytopenia (ETV6-RT), and familial platelet disorder predisposing to acute myeloid leukemia (FPD/AML) are three HT linked to specific predispositions to hematological malignancies [13,48]. The gene discussed is ANKRD26; the disease is hematologic disorder.