Notably, higher levels of interferons IFNα-1/13 IFNα-2 were observed in early time points for low-severity trajectory groups 1 to 3 and at later time points for higher-severity trajectory groups 4 and 5, which may align with findings from other studies that highlight their crucial roles in the COVID-19 immune response.27 This evidence concerns the gene IFNA1 and COVID-19.