Figure S2 further demonstrates that these longitudinal differences begin to emerge near the time of admission, within the first 30 d, as observed for proteins such as IL-10 and IL-5. Interestingly, IFNα-1/13 and IFNα-2, which were reported as markers for COVID-19 severity,27 exhibited higher levels at earliest time points for trajectory groups 1 to 3. This evidence concerns the gene IFNA2 and COVID-19.