On the other hand, even thoughlower circulating levels of adiponectin have been associated withobesity and insulin resistance,, it has also been describedhow this could mean a turnover in the resistance to adiponectin causedby the high-fat diet, which has been described in the literature.−,  This could lead to L. sakei-treatedrats needing lower levels of circulating adiponectin to fulfill itsfunction, and explain the reduced levels in the expression of the Adipoq gene induced by the probiotic. Here, ADIPOQ is linked to Insulin resistance.