People suffering from obesity show an elevated secretionof pro-inflammatory cytokines, including TNF-α, IL-6, and MCP-1from the hypertrophied adipose tissue, which contributes to systemicinflammation. In this regard, we evaluatedcirculating levels of the inflammatory markers MCP-1 and CRP-1. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.