The gene expressionanalyses performed in mesenteric fat depotsrevealed a significant reduction in the gene expression of the Lep gene, coding for leptin, an adipokine that plays a crucialrole in body weight regulation and lipolysis, and that has been stronglyassociated with obesity., The lower fat accumulationin subcutaneous adipose tissue has already been linked to lower leptincirculating levels., Thus, the reduced levels of thisadipokine might be explained by the reduction in mesenteric and subcutaneousfat depots induced by the probiotic. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.