In support of this, our previous work has shown that SH3 and multiple ankyrin repeat domains 3 (Shank3)-deficient mice, a model for neurodevelopmental disorder with autistic symptomatology, exhibit an imbalance between excitatory and inhibitory neurotransmission, characterized by reduced GABAergic markers, and altered social behavior and anxiety [9]. Here, SHANK3 is linked to neurodevelopmental disorder.