SLE patients had increased type I (33.6 [25.8, 45.5], ng/mL), type III (12.4 [9.8, 16.1] ng/mL), type IV (32.6 [26.9, 42.7] ng/mL) and type VI (18.0 [14.3, 25.9] ng/mL) collagen degradation compared to healthy donors (p<0.001 for all, except type IV p=0.003). The gene discussed is SGCG; the disease is systemic lupus erythematosus.