Five variants in UGT1A1 gene causing Crigler-Najjar syndrome, type I/II were detected in four unrelated patients (3 homozygous and 1 compound-heterozygous), while two unrelated patients were reported with two disease causing variants in the ABCC2 gene causing Dubin-Johnson syndrome (Table 5; Fig. 2D). This evidence concerns the gene ABCC2 and Dubin-Johnson syndrome.