As for the eight genetically confirmed children presenting with acute liver-cell failure they were suffering from galactosemia (GALT gene, 4 patients/3 variants) and three different types of mitochondrial depletion syndromes (MTDPS): DGUOK gene (MTDPS3, 2 patients/2 variants), MPV17 (MTDPS6, 1 patient/1 variant) and POLG (MTDPS4, 1 patient/2 variants) (Table 4; Fig. 2C). This evidence concerns the gene POLG and galactosemia.