Another value for NGS in early onset cholestasis is to identify the defect causing low-GGT PFICs (PFIC1, PFIC2, PFIC4 and the recently discovered MYO5B-associated cholestasis (PFIC10) (Gomez-Ospina et al. 2016; Qiu et al. 2017). This evidence concerns the gene ABCB11 and cholestasis.