A significant elevation of CRS associated proinflammatory cytokines IL-6 (P = 0.003), TNF-α (P = 0.041) and IFN-γ (P = 0.027) were observed in IL-2Ra KO mice after 4 weeks of WT CAR-T treatment (Figure 2, B–D). Here, TNF is linked to congenital rubella syndrome.