These BMDMs (from Group 1) were distinctly polarized toward the M1-like phenotype (CD86+MHCII+iNOS+) (P = 0.004), where iNOS expression is associated with CRS (Figure 4L), as compared with the M2-like phenotype (CD206+Arginase1+) (Figure 4M). The gene discussed is CD86; the disease is congenital rubella syndrome.