Gene set enrichment analysis (GSEA) (45) of cancer hallmarks pathways in neutrophils showed upregulation of IFN-γ response genes in Group 1 compared with Group 2 (Figure 6C), which is confirmed by higher expression of IFN-γ–inducible guanylate binding proteins (Gbp2, Gbp4, Gbp6, and Gbp7) (47) (Figure 6D). This evidence concerns the gene GBP4 and cancer.