LEP and obesity due to melanocortin 4 receptor deficiency: The “AA” genotype increases the risk of IR (20,21), hyperglycemia (21), T2DM (22), gestational diabetes mellitus (21), obesity (23), and hypertension (25,26) too.Moreover, the -2548 “A” allele is a risk factor for diabetes (21) and IR (23) compared to the “G” allele.Consequently, the results of our study showing the LEP -2548G>A“GG” genotype acts as a marker of decreased risk for MASLD are consistent with theconsiderations above.