Heterozygous pathogenic variants in PRODH have been associated with an increased risk of schizophrenia (Kolar et al. 2023), and proximal deletions excluding TBX1 but showing syndromic features (particularly neurological ones) have suggested candidate genes such as DGCR6 (OMIM *601279) and PRODH (Carli et al. 2021; Zamariolli et al. 2023). Here, PRODH is linked to schizophrenia.