However, nephrin ectodomains can be shed from the podocyte cell surface by the actions of metalloproteinases such as MMP‐7, which are markedly elevated in glomerular diseases (Tan et al., 2019) and which can be induced by NFAT signaling cascades in other cell types (Tie et al., 2013; Wang et al., 2015). Here, NPHS1 is linked to glomerular disorder.