Notably, Mlf2, an interaction partner of Mlf1 [37], has been shown be enriched in protein aggregates in human desminopathies [24] thus highlighting a novel and conceivable disease link between Mlf1 and Mlf2 related transcriptional control and Dnajb6 and Bag3 mediated protein quality control. The gene discussed is BAG3; the disease is Desminopathy.