DES and Desminopathy: Of particular interest was the down‐regulation of the mitochondrial proton gradient‐dependent carriers Slc25a3 (phosphate carrier), Slc25a4 (ADP/ATP translocase 1) and Slc25a12 (calcium‐binding carrier Aralar1, electrogenic aspartate/glutamate antiporter), all of which have been described to be down‐regulated in mitochondria purified from R349P desminopathy myotubes and/or in soleus muscle tissue from R349P desmin knock‐in mice ([28] and supplementary tables therein).