Kupffer cells (KCs), originally resided within the peri-portal area, are persistently recruited to the HBV-enriched peri-central region via increased CXCL9 produced by endothelial cells, facilitating the interaction between KCs and HBV<sup>+</sup> hepatocytes to induce LXRα deficiency-mediated lipid metabolism disorders (LMD) in KCs. Here, NR1H3 is linked to Langer mesomelic dysplasia.