Interestingly, 203 upregulated and 212 downregulated genes, including Krt5, Krt14, Col17a1, and Pgam1‐ps1 (Figure 7I,J; Table S1, Supporting Information), were shared between EC‐specific KO and Vasculotide‐treated mice, indicating mutual pathways underlying the endothelial EphA4/Tie2 axis following ischemic stroke. This evidence concerns the gene KRT5 and ischemic stroke.