This approach was utilized in the identification of an octameric protein module disrupted in many individuals with Bardet–Biedl syndrome, the BBSome (see Glossary) (Loktev et al., 2008; Nachury et al., 2007), using one of the known BBS-associated proteins, BBS4, as a bait. Here, BBS2 is linked to Bardet-Biedl syndrome.