FXYD3 belongs to the FXYD domain‐containing Na+/K+ ATPase regulatory factor family and is highly expressed in various malignant tumors, including breast, prostate, and pancreatic cancer.[25, 26, 27, 28] Although this protein is associated with unfavorable prognostic factors, such as invasion, migration, and lymph node involvement,[29] its role in ICC progression remains unclear. This evidence concerns the gene FXYD3 and cancer.