In the subsequent clinicopathological analysis (Table 1), the high FXYD3 group was significantly associated with large bile duct‐type ICC, poor differentiation (P = 0.001), poorer disease‐free survival (DFS, P = 0.004), and overall survival (P < 0.001) compared to the low FXYD3 group. The gene discussed is FXYD3; the disease is intrahepatic cholangiocarcinoma.